摘要目的 研究哈尔滨市人群的饥荒暴露对中老年期糖尿病、肥胖、高血压、冠心病和脑卒中等慢性病患病风险的影响.方法 以中国慢性病前瞻性研究(China Kadoorie Biobank,CKB)项目哈尔滨市的基线调查人群为研究对象,采用回顾性队列研究设计,应用logistic分析比较饥荒暴露人群与非饥荒暴露人群中老年期糖尿病、肥胖、高血压、冠心病和脑卒中等慢性病患病风险的差异.结果 调整影响因素后,饥荒暴露人群的肥胖(OR=1.204,95％CI:1.104～1.313,P＜0.01)、高血压(OR=1.315,95％CI:1.210 ～ 1.429,P＜0.01)和冠心病(OR=1.495,95％C1:1.369～1.632,P＜0.01)的危险性高于非饥荒暴露人群.饥荒暴露年龄越小,中老年期各种慢性病发生风险越大.结论 饥荒暴露是肥胖、高血压和冠心病的危险因素.保证生命全过程,尤其是生命早期和青少年期的营养充足对预防中老年期肥胖、高血压和冠心病具有重要意义.

abstractsObjective To study the relations between famine exposure and the risk of chronic diseases as diabetes mellitus,obesity,hypertension,coronary heart disease and stroke in the population of Harbin.Methods Our data was collected from the baseline survey-the China Kadoorie Biobank project (CKB) in Harbin.Retrospective cohort study design was used.Related risks on chronic diseases including diabetes mellitus,obesity,hypertension,coronary heart disease and stroke,were compared among the famine exposed or non-exposed people,respectively by logistic analysis method.Results After adjusted for factors as age,sex,physical activity,smoking,alcohol intake,diet,family history of diseases,it appeared that the factor ‘ famine exposure'had increased the risks of diseases as obesity (OR=1.204,95％CI:1.104-1.313,P＜0.01),hypertension (OR=1.315,95％CI:1.210-1.429,P＜0.01) and coronary heart disease (OR=1.495,95％CI:1.369-1.632,P＜0.01).The lower the age of population being exposed to famine,the greater the risk of the development of all kinds of chronic diseases.Conclusions Famine exposure appeared a risk factor for obesity,hypertension,and coronary heart disease.It is of great significance to ensure the life-long nutrition of the people,especially in the early and adolescent stages,to prevent obesity,hypertension,and coronary heart disease in their later lives.