摘要目的 探讨月经初潮年龄与女性成年后近、远期肥胖的关系.方法 以中国慢性病前瞻性研究项目苏州点2004-2008年调查的具有完整初潮与身体测量数据信息的30 895名女性为研究对象,将初潮年龄分为3组:≤12、13～ 16、≥17岁,其中≤12岁初潮年龄为过早.采用多因素logistic回归分析月经初潮年龄对女性成年后近、远期肥胖的影响.结果 调查对象月经初潮年龄为(15.64±1.92)岁,1 421人(4.6％)月经初潮过早.随着出生年代的推迟,女性月经初潮年龄有不断提前的趋势.调查对象成年后近期肥胖803人(2.6％),远期肥胖3 738人(12.1％).调整年龄、生活方式、高血压、糖尿病、绝经状态等因素后,月经初潮年龄过早是女性成年后发生近、远期肥胖的危险因素,OR值(95％CI)分别为2.45(1.74～ 3.45)和1.99(1.69 ～ 2.34).月经初潮年龄与绝经状态对远期肥胖无相乘交互作用(P=0.324).结论 月经初潮过早是女性成年后发生近期肥胖和远期肥胖的危险因素.

abstractsObjective To study the relationship between the age of menarche and the nearterm/long-term obesity in adult women.Methods We analyzed the baseline data of 30 895 women with complete data on menarche and body measurement that was from the China Kadoorie Biobank (CKB) study from 2004 to 2008.The age of menarche was divided into three groups:≤12,13-16 and ≥ 17 years old.Prematurity was set at age ≤ 12 years.Multivariate logistic regression was used to analyze the effects of menarche age on the near/long-term obesity in female adults.Results The average menarche age of respondent appeared as (15.64 ± 1.92) years old,with prematurity number as 1 421,accounting for 4.6％ of the total numbers.Regarding the postponing of dates of birth,the age of menarche in women showed an advancing tendency.Among all the adult women under study,803 developed near-term obesity,with the prevalence as 2.6％,while the number of long-term obesity was 3 738,accounting for 12.1％.Refining factors of age,lifestyle,menopausal status,hypertension and diabetes showed that the menarche age was related to the risks of both short-term and long-term obesity in women and the ORs (95％CI) were 2.45 (1.74-3.45) and 1.99 (1.69-2.34),respectively.There was no multiplicative interaction shown between the menarche age and menopausal status on long-term obesity (P=0.324).Conclusion Premature menarche appeared a risk factor for near-term/long-term obesity in adult females.