摘要目的 探讨陕西地区育龄妇女围孕期用药与活产单胎新生儿早产的关系.方法 采用分层多阶段随机抽样方法,以问卷调查方式收集2010-2013年陕西省怀孕且结局明确的育龄妇女及其子女的相关信息.计数资料采用百分比描述,计量资料采用-x±s描述,用多阶段复杂抽样logistic回归分析围孕期用药与新生儿早产的关系.结果 陕西省活产单胎新生儿早产的发生率为2.7％.在28 841例调查对象中,围孕期用药者占15.8％.妇女围孕期使用最多的药物为感冒药1 702例(5.9％).在控制混杂因素后,围孕期服用激素类药物者新生儿早产的发生率是未服用者的2.23倍(OR=2.23,95％CI:1.19～4.18)、服用抗高血压药者是未服用者的7.74倍(OR=7.74,95％CI:4.28～13.95)、服用其他药物者是未服用者的2.15倍(OR=2.15,95％CI:1.60～2.89).结论 陕西省育龄妇女围孕期服用激素类、抗高血压和其他药物会增加早产的罹患风险.

abstractsObjective To understand the relationship between medication during pregnancy and single live preterm birth of infant in women of childbearing age in Shaanxi province.Methods A cross-sectional design was used in this study and stratified multistage random sampling method was used.A questionnaire survey was conducted in the childbearing-aged women selected through multi stage stratified random sampling in Shaanxi during 2010 to 2013.Qualitative datum was described by percentage and measurement datum was described by mean ± standard deviation.Logistic regression analysis was done to evaluate the relationship between medication during pregnancy and preterm birth of infant.Results The overall incidence rate of premature birth was 2.7％ in Shaanxi.Among the 28 841 mothers participating in this study,the proportion of medication use at any time during pregnancy was 15.8％,and the most commonly used drug was cold medicine (5.9％).After adjusting all confounding factors,the multivariable logistic regression analysis results showed that taking hormone medicine (OR=2.23,95％CI:1.19-4.18),antihypertensive medicine (OR=7.74,95％CI:4.28-13.95) and other medicines (OR=2.15,95％CI:1.60-2.89) during early pregnancy were the risk factors for preterm delivery,the risk was 2.23 times,7.74 times and 2.15 times higher compared with those taking no these medicines.Conclusion Using hormone medicine,antihypertensive medicine and other medicines during pregnancy increased the risk for preterm delivery in women of childbearing age in Shaanxi.