摘要目的 探索肿瘤坏死因子受体超家族成员11A(TNFRSF11A)和11B(TNFRSF11B)基因多态性与丙型肝炎病毒(HCV)感染转归的关系.方法 以2008-2016年纳入的749例持续感染者、494例自限清除者和1 486例对照者作为研究对象开展病例对照研究,利用TaqMan-MGB探针法检测TNFRSF11A rs1805034和TNFRSF 11B rs2073617两个位点的基因型,分析它们在不同人群中的分布情况.结果 共显性模型结果显示,与携带TNFRSF11B rs2073617 TT基因型的个体相比,携带CC基因的个体易发生HCV感染慢性化(OR=1.517,95％CI:1.055～2.181,P=0.024).隐性模型结果显示,与携带rs2073617 TT或TC基因型的个体相比,携带CC基因的个体易发生HCV感染慢性化(OR=1.435,95％CI:1.033～1.996,P=0.032);相加模型显示,随着携带C等位基因个数的增加,个体发生HCV感染慢性化的风险亦可增加(OR=1.204,95％CI:1.013～1.431,P=0.035).结论 TNFRSF 11B rs2073617的基因多态性与HCV感染慢性化可能存在关联.

abstractsObjective To explore the relationship between the tumor necrosis factor receptor superfamily members 11A (TNFRSF11A) and 11B (TNFRSF11B) gene polymorphisms and the outcome of hepatitis C virus (HCV) infection.Methods In this case-control study,749 cases of persistent HCV infection,494 cases of spontaneous clearance and 1 486 control subjects were included from 2008 to 2016.TaqMan-MGB probe method was used to detect the genotype of TNFRSF11A rs1805034 and TNFRSF11B rs2073617.The genotypes distribution of the two single nucleotide polymorphisms (SNP) were analyzed in different populations.Results Co-dominant model showed that individuals carrying the rs2073617 CC genotype were prone to have chronic HCV infection,compared with individuals carrying the rs2073617 TT genotype (OR =1.517,95％ CI:1.055-2.181,P=0.024).Recessive model results showed that individuals carrying rs2073617 CC genotype were more likely to develop chronic HCV infection compared with individuals carrying rs2073617 TT or TC genotype (OR=1.435,95％CI:1.033-1.996,P=0.032).Additive model showed that the risk for chronic HCV infection increased with the increase of the number of rs2073617 C alleles (OR=1.204,95％CI:1.013-1.431,P=0.035).Conclusion The genetic polymorphism of TNFRSF11B rs2073617 might be related with the chronicity of HCV infection.