摘要目的:探讨苏州市成年人睡眠时长与慢性阻塞性肺疾病（COPD）发病的前瞻性关联。方法:利用中国慢性病前瞻性研究苏州市吴中区项目点53 269名30~79岁调查对象的基线和随访信息，基线调查开展于2004-2008年，本研究使用的数据随访截至2017年12月31日。剔除基线气流阻塞者、基线调查时自报患有慢性支气管炎/肺气肿/肺心病、数据异常或缺失的研究对象后，最终纳入分析45 336名。利用Cox比例风险回归模型分析睡眠时长与COPD发病风险的关联，并计算发病风险比（ HR）值及其95% CI。按照年龄、性别、生活方式等因素进行分层分析，根据吸烟状况和每日睡眠时长交叉分组进行联合分析。 结果:研究对象中位随访时间为11.12年，随访期间共诊断COPD 515名。调整潜在混杂因素后，多因素Cox比例风险回归分析显示，每日睡眠时长≥10 h增加COPD发病风险（ HR=1.42，95% CI：1.03~1.97）。联合分析结果显示，睡眠时长过长（≥10 h）可显著增加吸烟者COPD发病风险（ HR=2.49 ，95% CI：1.35~4.59，交互作用 P<0.001 ）。 结论:每日睡眠时长过长（≥10 h）可以增加苏州市成年人中COPD发病风险，在吸烟者中更加明显。

abstractsObjective:To investigate the prospective association of sleep duration with the development of chronic obstructive pulmonary disease (COPD) in adults in Suzhou.Methods:The study used the data of 53 269 participants aged 30-79 years recruited in the baseline survey from 2004 to 2008 and the follow-up until December 31, 2017 of China Kadoorie Biobank (CKB) conducted in Wuzhong District, Suzhou. After excluding participants with airflow limitation, self-reported chronic bronchitis/emphysema/coronary heart disease history at the baseline survey and abnormal or incomplete data, a total of 45 336 participants were included in the final analysis. The association between daily sleep duration and the risk for developing COPD was analyzed by using a Cox proportional hazard regression model, and the hazard ratio ( HR) values and their 95% CI were calculated. The analysis was stratified by age, gender and lifestyle factors, and cross-analysis was conducted according to smoking status and daily sleep duration. Results:The median follow-up time was 11.12 years, with a total of 515 COPD diagnoses in the follow-up. After adjusting for potential confounders, multifactorial Cox proportional hazard regression analysis showed that daily sleep duration ≥10 hours was associated with higher risk for developing COPD ( HR=1.42, 95% CI: 1.03-1.97). The cross analysis showed that excessive daily sleep duration increased the risk for COPD in smokers ( HR=2.49, 95% CI: 1.35-4.59, interaction P<0.001). Conclusion:Longer daily sleep duration (≥10 hours) might increase the risk for COPD in adults in Suzhou, especially in smokers.