摘要目的 评价异丙酚是否可诱发大鼠精神依赖性.方法 清洁级雄性SD大鼠24只,体重240～270 g,周龄14周,麻醉下右颈外静脉置管,7d后开始连续14 d的自身给药实验.随机分为4组(n=6):脂肪乳对照组(C组)、异丙酚0.56 rag/ks组(P1组)、异丙酚1.00 mg,kg组(P2组)和异丙酚1.70 rag/ks组(P1组).实验由计算机控制,每天限定最高注射次数为50次,P1组、P2组和P3组每次分别静脉注射异丙酚0.56、1.00、1.70 mg/kg,C组静脉注射脂肪乳0.1ml/kg.记录大鼠每天有效鼻触次数、无效鼻触次数、注射药物次数及最后3d异丙酚日注射量.结果 与C组和P1组比较,P2组和P1组有效鼻触次数和注射药物次数增加(P<0.01);与P2组比较,P3组有效鼻触次数和注射药物次数增加(P<0.01).C组与P1组有效鼻触次数和注射药物次数比较差异无统计学意义(P>0.05);4组间无效鼻触次数比较差异无统计学意义(P>0.05).P1组、P2组和P3组最后3d异丙酚日注射量呈剂量依赖性(P<0.01).结论 异丙酚诱发大鼠精神依赖性,与其剂量有关.

abstractsObjective To assess whether propofol call induce stable psychic dependence in the rats by self-administration experiment. Methods Twenty-four male SD rats 14 weeks old weighing 240一270 mg were studied. Anesthesia was performed with intraperitoneal injection of 3%sodium pentoharbitsl 40 ms/kg and atropine 03 mg/kg.A catheter wag inserted into the right external jugular vein. Penicillin(100 000 U)0.2 ml wag injected through the external jugular vein for anti-infection and heparin sodium(50U/ml)0.1 ml for anticoagulation. The self-administration experiment of 14 days was started after the 7 days of recovery. All the rats were randomly divided into 4 groups(n=6 each):contontrol group(C),propofol 0.56 mg/kg/l group(P1),propofol 1.00 mg/kg group(P2)and pmpofol 1.70 ms/kg group(P3).The experimental events were controlled by a computer with 50 times of the maximum injection per day.The times ofactive and inactive nose-poke response and times of drug iniection were recorded per day.Results Compared with group C and P1,the times of active nosepoke response and injections were significantly increased in group P2 and P3(P<0.01).The times of active nosepoke response and injections per day were significantly increased in group P3 than in group P2(P(0.01).There was no significant difference in the times of active nose-poke response and injections between group C and P1.There was no significant difference in inactive nose-poke resporme between the 4 groups.And the total daily doses of propofol injected in the last 3 days were significantly increased in a dose-dependent manner.Conclusion Propefol can induce the development of psychological dependence in rata and it is related to the dosage.