摘要目的：比较靶控输注瑞芬太尼和舒芬太尼复合异丙酚用于局部麻醉患者镇静镇痛术的效应。方法局麻辅助镇静镇痛术下接受择期整形外科手术的患者60例，年龄17～54岁，ASA分级Ⅰ或Ⅱ级，体重指数＜30 kg／m2，采用随机数字表法分为2组（ n＝30）：瑞芬太尼组（ R组）和舒芬太尼组（ S组）。 R组靶控输注异丙酚（初始靶浓度1．0μg∕ml）和瑞芬太尼（初始靶浓度1．0 ng∕ml），S组靶控输注异丙酚（初始靶浓度1．0μg∕ml）和舒芬太尼（初始靶浓度0．1 ng∕ml），术中调整药物靶浓度，维持改良OAA∕S评分2或3分，记录疼痛反应、低氧血症、呼吸过缓和∕或暂停的发生情况，计算异丙酚总用量。结果2组患者术中疼痛反应、低氧血症、呼吸过缓和∕或暂停的发生率和异丙酚用量差异无统计学意义（ P＞0．05）。结论靶控输注瑞芬太尼复合异丙酚用于局部麻醉患者镇痛镇静术的效应与靶控输注舒芬太尼复合异丙酚的效应相似。

abstractsObjective To compare remifentanil?propofol target?controlled infusion ( TCI ) with sufentanil?propofol TCI for sedation and analgesia in the patients undergoing local anesthesia. Methods Sixty patients, aged 17?54 yr, with body mass index <30 kg∕m2, scheduled for elective plastic surgery underlocal anesthesia, were equally and randomly divided into remifentanil group (group R) and sufentanil group(group S) by using a random number table. Remifentanil (the initial target plasma concentration 1?? 0ng∕ml) and propofol (the initial target plasma concentration 1?? 0 μg∕ml) were given by TCI in group R.Sufentanil (the initial target plasma concentration 0?? 10 ng∕ml) and propofol (the initial target plasma con?centration 1?? 0 μg∕ml) were given by TCI in group S. The target plasma concentration was adjusted to main?tain the modified Observer′s Assessment of Alertness∕Sedation Scale score of 2 or 3. The occurrence of painresponses, hypoxemia, bradypnea and∕or apnea was recorded during operation. The total amount of propofolconsumed was calculated. Results There was no significant difference in the incidence of pain response,hypoxemia, bradypnea and∕or apnea, and total amount of propofol consumed between the two groups (P >0?? 05). Conclusion Remifentanil?propofol TCI provides similar sedative and analgesic efficacy to that a?chieved by sufentanil?propofol TCI in the patients undergoing local anesthesia.