摘要目的 评价右美托咪定对非体外循环冠脉搭桥术患者术后转归的影响.方法 择期行非体外循环冠脉搭桥术患者122例,性别不限,年龄40～75岁,BMI 18.5～32.0 kg∕m2,ASA分级Ⅲ或Ⅳ级,NYHA心功能分级Ⅱ或Ⅲ级,左室射血分数>40％.采用随机数字表法分为2组(n=61):右美托咪定组(D组)于麻醉诱导前15 min静脉输注右美托咪定0.6μg∕kg负荷量,术中以0.4μg·kg-1·h-1的速率持续输注直至手术结束;对照组(C组)给予等体积生理盐水.记录苏醒时间ICU滞留时间、气管拔管时间和术后住院时间.结果 与C组比较,D组气管拔管时间、ICU滞留时间和术后住院时间缩短,苏醒时间延长(P<0.05).结论 右美托咪定可促进非体外循环冠脉搭桥术患者术后转归.

abstractsObjective To evaluate the effect of dexmedetomidine on postoperative outcomes in pa-tients undergoing off-pump coronary artery bypass grafting ( OPCABG) . Methods One hundred and twen-ty-two patients of both sexes, aged 40-75 yr, with body mass index of 18. 5-32. 0 kg∕m2 , of American So-ciety of Anesthesiologists physical status Ⅲ or Ⅳ, with New York Heart Association Ⅱ or Ⅲ, with lelf ventricular ejection fraction>40％, scheduled for elective OPCABG, were divided into 2 groups ( n=61 each) using a random number table method: dexmedetomidine group ( group D) and control group ( group C) . Dexmedetomidine was intravenously infused in a loading dose of 0. 6μg∕kg at 15 min before anesthesia induction, followed by a continuous infusion of 0. 4 μg · kg-1 · h-1 until the end of surgical procedure in group D. The equal volume of normal saline was given instead in group C. The emergence time, extubation time, length of intensive care unit stay and postoperative length of hospital stay were also recorded. Results Compared with group C, the extubation time, length of intensive care unit stay, and postoperative length of hospital stay were significantly shortened, and the emergence time was prolonged in group D ( P<0. 05) . Conclusion Dexmedetomidine can promote postoperative outcomes in the patients undergoing OPCABG.