摘要近年来发表了三项长期、随机对照试验(ACCORD,ADVANCE,VADT)和两项长期流行病学随防研究(UKPDS,STENO-2),其结果均比较了2型糖尿病中强化降糖和标准化降糖对心血管预后的影响.本文就七述研究结果,综合相关文件进行复习和解析.提出:严格控制血糖仍为心血管疾病风险管理的基础治疗之一;同时应更加关注降糖治疗的安全性和个体化.只有遵循已有证据,结合自身lIi{i床实践,才能不断提高我国2型糖尿病及其并发症的防治水平.

abstractsRecently, several large, long-term rendomized controlled trails (ACCORD, ADVANCE, VADT) and long-term epidemiologic follow-up studies (UKPDS, STENO-2) have compared the effects of intensive versus standard glycemic control on cardiovascular disease events. Based on reviewing aforementioned studies, the present article would suggest that intensive glycemia control is still considered as one of the principal therapies for the prevention of cardiovascular events in diabetes while stressing on safety and individualization for glucose-lowering strategy.