宫内发育迟缓大鼠不同阶段胰岛功能及胰岛素敏感性的研究
Study on pancreatic islet β-cell function and insulin sensitivity at different stages of lifetime in rats born with intrauterine growth retardation
摘要采用营养不良法建立官内发育迟缓(intrauterine growth retardation,IUGR)大鼠模型,发现IUGR大鼠胰腺发育受损、胰岛β细胞功能减退,随年龄增长逐渐出现糖耐量受损及胰岛素敏感性下降.
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abstractsThe intrauterine growth retardation (IUGR) model was established by maternal nutrition restriction during mid- to late-gestation. IUGR rats had both impaired pancreatic development and islet β-cell dysfunction. As the animals grew, the rats gradually showed impaired glucose tolerance and decreased insulin sensitivity.
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