摘要目的 分析以严重骨痛为主要临床表现的5例干燥综合征患者的临床特点.方法 回顾性分析本院内分泌科5例符合上述特征的病例.结果 患者均为女性,平均病程9.5年,均表现为明显骨痛和肌肉无力不适,活动受限同时有程度不同的外分泌腺受累表现.患者存在不同程度酸中毒、钙磷代谢紊乱和活性维生素D3生成障碍,其中3例肌肉活检提示肌肉病变同时存在高胰岛素血症.结论 患者出现骨关节症状时应注意寻找系统因素,同时不能忽略肌肉病变,应以整体观念看待疾病.

abstractsObjective To analyze the clinical characteristics of five Sj(o)gren's syndrome (SS) patients with severe ostalgia. Methods Five SS patients from the endocrinology department of our hospital were retrospectively analyzed. Results All the patients were female, with 9.5 year average course of disease, obvious ostalgia, muscle weakness and complaint, limitation of activity, and different degree of exocrine gland impairment. All the patients had different degree of acidosis, disorders of calcium and phosphorus metabolism, and dyspoiesis of calcitriol. Among them, three patients were found to have hyperinsulinemia and muscle pathological changes detected by the biopsy. Conclusions System factors must be investigated when patients present the bone symptom. At the same time, muscle problem should not be neglected and the patients should be treated as an entirety.