摘要临床前瞻性观察和动物实验研究均表明妊娠早期亚临床甲状腺功能减退症能够导致后代智力受损,及时诊断和有效的治疗有可能预防这些危害.所以,我们建议在妊娠早期(最好在妊娠8周前)对妇女、特别是对有甲状腺疾病危险因素的妇女积极筛查甲状腺功能,对妊娠期亚临床甲减妇女进行左旋甲状腺素(L-T4)干预治疗,启动时机应当在12周前,干预期间需要密切监测甲状腺功能,及时调整L-T4剂量,尽早达标,以保证正常的胎儿脑发育和后代智力发育.

abstractsStudies from clinical observation and animal experiments have indicated that maternal subclinical hypothyroidism during the first gestational term may lead to impairment of brain development of offspring, and early diagnosis and effective treatment may prevent the damage. Therefore, we suggest that it is pertinent to screen thyroid function before gestational 8 weeks in pregnant women, especially for those who have risk factors of thyroid diseases. We also suggest that maternal subclinical hypothyroidism should be treated with levo-thyroxine ( L-T4 ) before 12 gestational weeks. Thyroid function should be measured regularly in order to adjust the dosage of L-T4 and reach the goal of treatment on time, so as to protect the brain development of fetus and offspring.