摘要以蒙特利尔认知评估量表(MoCA)、脑诱发电位失匹配负波(MMN)为工具选取98例2型糖尿病合并轻度认知功能损害患者.选择其中48例患者在常规治疗同时给予尼莫地平20 mg/d(用药组),观察与其他50例患者(对照组)18个月后MoCA、MMN的变化.两组间MoCA评分未见明显差异(P＞0.05).用药组MMN的潜伏期、波幅较治疗前改善,差异有统计学意义(P＜0.05);对照组MMN的波幅较治疗前进一步降低,差异有统计学意义(P＜0.05),但MMN潜伏期治疗前后没有显著性差异(P＞0.05).

abstractsNinty-eight patients of type 2 diabetes mellitus with mild cognitive impairment were collected according to the Montreal Cognitive Assessment( MoCA )and mismatch negativity( MMN ).Forty-eight patients were assigned to conventional treatment with nimodipine (20 mg/d).The MoCA and MMN were evaluated and compared with the remaining 50 patients who served as a control group.There was no significant difference between two patient groups in MoCA( P＞0.05 ) ;the latency and amplitude of MMN were significantly improved in the treated group( P＜0.05 ) ; the amplitude of MMN was reduced in control group ( P＜0.05 ),but the latency of MMN showed no significant change( P＞0.05 ).