换一批
换一批摘要证据提示脂联素在卵巢分泌类固醇激素和胎盘发育中发挥了重要的作用.其不仅直接影响晚期卵泡的合成,还影响胰岛素与促性腺激素释放激素作用从而影响初始卵泡形成.脂联素通过多种信号途径对卵巢功能和胎盘形成具有潜在性的作用,为代谢及生殖相关疾病的病因学研究和治疗提供新的思路.
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abstractsThere is a strong support for a role played by adiponectin in the function of ovary and placenta.There is evidence of direct effects of adiponectin on the late stages of folliculogenesis,and additive interactions of adiponectin with insulin and gonadotropins in inducing periovulatory changes in ovarian follicles.Adiponectin has demonstrated a potential effect on ovarian function as well as a possible effect on the formation of placenta,via multiple mechanisms,providing new strategies for the etiology investigation,prevention and treatment of reproductive and related metabolic diseases.
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关键词
脂联素脂联素受体信号途径卵巢功能多囊卵巢综合征AdiponectinAdiponectin receptorSignal pathwayOvary functionPolycystic ovary syndrome
分类号
R781.63
栏目名称
综述
DOI
10.3760/cma.j.issn.1000-6699.2012.04.023
发布时间
2012-07-17
基金项目
上海市科委重点科技攻关项目
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