摘要6例畸形性骨炎患者(男5,女1),平均年龄为(57.7±11.8)岁,平均病程为(7.5±6.5)年。临床症状均表现为受累骨骼疼痛,病变主要累及骨盆和股骨。 X 线摄片均显示畸形性骨炎特征性的改变。骨扫描检查显示受累骨骼的核素异常浓聚。 6例患者的血清碱性磷酸酶(ALP)均有不同程度升高,中位数为235 U/ L。5例患者予唑来膦酸钠静脉滴注治疗,治疗后3个月疼痛明显缓解,活动功能改善,血清 ALP水平下降,疗效明显。

abstractsSix cases of Paget′s disease of bone, including 5 males and 1 female, aged (57. 7 ±11. 8) years old, were recruited. Mean duration of disease was (7. 5±6. 5) years. Clinical manifestations were bone pain and bone deformity. The lesions mainly reside in the pelvis and femur. X-ray film showed typical lesion of Paget′s disease of bone, such as impaired bone trabecular structure with coarseness and disorder, cortical thickening, medullary cavity narrowing and skeletal deformation. Bone scan revealed abnormal radionuclide concentration in the involved bone. Serum alkaline phosphatase ( ALP) in 6 patients was increased ( median 235 U/ L). 5 patients received zoledronic acid sodium intravenous infusion therapy. Bone pain was relieved obviously in 5 patients after treatment for 2-3 months. Physical activity was greatly improved, and serum ALP levels significantly decreased.