摘要目的：综合评价2型糖尿病患者应用磺脲类降糖药物与脑中风风险性的关联性。方法通过文献检索收集符合入组条件随机对照研究( random control trails, RCT),比较2型糖尿病患者应用磺脲类药物与对照剂相比脑中风发生风险差异。使用Stata 12.0和Rev Man 5.2进行meta分析,以漏斗图检验入选文献的发表偏倚。结果纳入RCT研究17项,采用随机效应模型对脑中风发生事件进行分析,应用磺脲类降糖药物组脑中风风险性较对照组升高(RR 1.35,95% CI 1.13~1.60)。17项研究异质性I2值为0.0%(P=0.687),漏斗图显示纳入研究间未见明显发表偏倚。结论2型糖尿病患者应用磺脲类降糖药物有可能是潜在脑中风风险性升高的危险因素。

abstractsObjective To investigate whether sulfonylurea ( SU) increases the risk of stroke in patients with type 2 diabetes mellitus(T2DM). Methods A systemic meta-analysis including 17 random control trails(RCT) was performed to compare the risk of stroke between type 2 diabetic patients treated with SUs and comparators. Results 1 612 articles were retrieved, and finally 17 articles were included. Patients receiving SUs treatment had a higher relative risk of stroke (RR 1. 35, 95% CI 1. 13-1. 60) than those who received comparators. The I2 statistic for heterogeneity between 17 trails was 0. 0%(P=0. 687). No major asymmetry appeared in the funnel plot and Begg′adjusted rank correlation test(kendall′s score=22, P=0. 387). Conclusion The use of SUs may raise the risk of stroke which is already high in patients with T2DM.