换一批摘要肾上腺皮质癌是一种预后差的罕见病，其分子发病机制主要与基因突变、类固醇生成因子1(Steroidogenic factor-1)、胰岛素样生长因子2、血管内皮生长因子等细胞生长因子表达异常、Wnt信号通路异常激活、miRNA失调和DNA甲基化等有关。近年随着相关研究的不断深入，从分子水平鉴别良恶性肾上腺皮质肿瘤为肾上腺皮质癌早期诊断提供了新的思路。
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abstracts[Summary] Adrenocortical carcinoma is a rare disease with poor prognosis, and its pathogenesis is mainly related to genetic mutations, abnormal expressions of steroidogenic factor-1, insulin-like growth factor 2,cell growth factors including vascular endothelial growth factor, dysfunction of Wnt pathway, as well as dysregulation of microRNA and DNA methylation. In recent years, the intensive molecular studies provide a brand-new methodology to distinguish adrenocortical carcinomas from benign tumors in early stage.
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关键词
肾上腺皮质癌类固醇生成因子1Wnt通路miRNAsDNA甲基化Adrenocortical carcinomaSteroidogenic factor-1Wnt signaling pathwayMicroRNAsDNA methylation
主题词
肾上腺皮质肿瘤(Adrenal Cortex Neoplasms)研究(Research)类固醇生成因子1(Steroidogenic Factor 1)甲基化(Methylation)分子生物学(Molecular Biology)
栏目名称
DOI
10.3760/cma.j.issn.1000-6699.2016.01.019
发布时间
2016-03-29（万方平台首次上网日期，不代表论文的发表时间）
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