摘要将143例痛风及高尿酸血症患者分为2型糖尿病组(n=43)、糖调节受损组(n=45)、糖耐量正常组(n=55).以1h血糖8.6 mmol/L为切点,再将糖耐量正常组分为1 h血糖≥8.6 mmol/L组(n=30)及1 h血糖<8.6 mmol/L组(n=25),比较4组间胰岛素第一时相及第二时相分泌功能指数.结果显示,糖调节受损、1 h血糖≥8.6 mmol/L、1 h血糖<8.6 mmol/L 3组间胰岛素第二时相分泌指标差异无统计学意义(P>0.05).糖调节受损组、1 h血糖≥8.6 mmol/L组的胰岛素第一时相分泌指标无显著差异(P>0.05),但均较1 h血糖<8.6 mmol/L组显著降低(P<0.05).修正的胰岛β细胞功能指数在1 h血糖<8.6 mmol/L、1 h血糖≥8.6 mmol/L、糖调节受损三组间依次降低(P<0.05).提示糖耐量正常的痛风及高尿酸血症患者1 h血糖≥8.6 mmol/L时已出现胰岛素第一时相分泌功能异常.

abstractsAll of 143 patients with gout or hyperuricemia were divided into type 2 diabetes(n=43), impaired glucose regulation(n=45),and normal glucose tolerance(n=55)groups. Moreover,a cut point of 8.6 mmol/L in one hour postload plasma glucose(1hPG)of oral glucose tolerance test was used to sub-divide the normal glucose tolerance group into 1hPG≥8.6 mmol/L(n=30)and 1hPG<8.6 mmol/L(n=25)groups. The first-and second-phase insulin secretion indexes were compared among four groups. The results showed that there was no statistical difference in the second-phase insulin secretion index among impaired glucose regulation,1hPG≥8.6 mmol/L,and 1hPG<8.6 mmol/L groups(P>0.05). The first-phase insulin secretion index revealed no significant difference between impaired glucose regulation and 1hPG≥8.6 mmol/L groups(P>0.05),but obviously decreased in these two groups compared with 1hPG<8.6 mmol/L group(P<0.05). The modified β cell function indexes were gradually decreased in 1hPG<8.6 mmol/L,1hPG≥8.6 mmol/L, and impaired glucose regulation groups(P<0.05). These results suggest that when 1hPG of the patients with gout and hyperuricemia is over 8.6 mmol/L,the first-phase insulin secretion will be impaired.