换一批
换一批摘要在嗜铬细胞瘤和副神经节瘤(统称为PPGL)中,与三羧酸循环相关的基因发生突变,会导致三羧酸循环中间代谢产物水平紊乱,通过激活缺氧诱导因子(HIF)可引发假性缺氧应答,还会导致表观遗传变异、阻碍细胞分化和凋亡,共同促进PPGL发生和发展.本文综述了目前三羧酸循环在PPGL发生机制中的基础研究进展以及相关检测方法的应用.
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abstractsIn pheochromocytoma and paraganglioma (PPGL), mutations in the TCA cycle related genes may lead to the disturbance of the TCA cycle's intermediate metabolite levels, then cause pseudohypoxia by abnormal hypoxia-inducible factor ( HIF) activation, it also may lead to epigenetic changes, impede cell differentiation and apoptosis, and finally promote the occurrence and development of PPGL. This review focus on the research advances on the TCA cycle in the pathogenesis of PPGL, as well as the application of relevant detection methods.
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栏目名称
综述
DOI
10.3760/cma.j.issn.1000-6699.2018.05.013
发布时间
2018-07-04
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- 被引1
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