摘要探讨3-硝基酪氨酸(3-NT)水平与新诊断2型糖尿病患者颈动脉粥样硬化的相关性.选取2017年2月至2017年12月于唐山工人医院内分泌科就诊的新诊断2型糖尿病患者96例作为研究对象,根据颈动脉超声检查结果将其分为颈动脉粥样硬化组(CAS组,n=54)和非颈动脉粥样硬化组(NCAS组,n=42).同时从医院健康体检中心选取非糖尿病健康人群51名作为正常对照组(NC组).收集其人口学资料及临床检验结果,采用酶联免疫吸附法(ELISA)检测血清3-NT水平.结果显示:(1)3组间3-NT水平比较,CAS组和NCAS组均高于NC组,CAS组高于NCAS组(均P<0.05);(2)在2型糖尿病患者中,3-NT与HbA1C、低密度脂蛋白胆固醇均呈正相关(均P<0.05);(3)在2型糖尿病患者中,经logistic回归分析发现,年龄(OR=1.271,P=0.023)、HbA1C(OR=1.812,P=0.005)、Hcy(OR=1.194,P=0.019)、3-NT(OR=1.593,P=0.011)均为颈动脉粥样硬化发生的危险因素.新诊断2型糖尿病患者血清3-NT与颈动脉粥样硬化相关,提示3-NT可能参与了颈动脉粥样硬化的发生及发展.

abstractsTo investigate the association of serum 3-nitrotyrosine ( 3-NT ) with carotid atherosclerosis in newly diagnosed type 2 diabetic patients. 96 patients with newly diagnosed type 2 diabetes mellitus treated in the department of endocrinology of Tangshan Gongren Hospital were recruited, and were divided into two groups depending on their carotid atherosclerosis status as carotid atherosclerosis group ( CAS group, n = 54 ) and non-carotid atherosclerosis group ( NCAS group, n=42); while 51 healthy subjects without type 2 diabetes mellitus from the medical examination center were recruited as normal control group ( NC group, n=51) . Demographic and clinical data of all subjects were collected. Serum 3-NT levels were measured by Enzyme-Linked Immunosorbent Assay ( ELISA) . ( 1) The levels of 3-NT in CAS group and NCAS group were all higher than those in NC group, and the level of 3-NT in CAS group was higher than that in NCAS group (all P<0.05);(2) In type 2 diabetic patients, 3-NT was positively correlated with HbA1C and low density lipoprotein-cholesterol ( both P<0. 05); ( 3) Logistic regression analysis showed that age (OR=1.271, P=0.023), HbA1C(OR=1.812, P=0.005) , Hcy (OR=1.194, P=0.019), and 3-NT (OR=1.593, P=0.011) were risk factors of CAS in type 2 diabetic patients. Serum 3-NT was closely correlated with carotid atherosclerosis in newly diagnosed type 2 diabetic patients, suggesting that serum 3-NT may be involved in the carotid atherosclerosis of newly diagnosed type 2 diabetic patients.