摘要目的:探讨三酰甘油葡萄糖(triglyceride-glucose, TyG)指数与碱性磷酸酶(alkaline phosphatase, ALP)对绝经后女性臂踝脉搏波传导速度(brachial-ankle pulse wave velocity, baPWV)的影响。方法:采用横断面研究，抽取2020年3月至2021年6月江苏省太湖疗养院体检绝经后女性人群3 483例，收集受检者运动、体重指数、收缩压、舒张压、空腹血糖、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、ALP、baPWV等资料。结果:baPWV正常组( n＝1 971)年龄、体重指数、收缩压、舒张压、空腹血糖、总胆固醇、低密度脂蛋白胆固醇水平均低于baPWV增高组( n＝1 512)，差异有统计学意义( P<0.001)。 Logistic回归分析显示，除年龄、体重指数、收缩压、舒张压、规律运动外，TyG指数( OR值为1.75)与ALP水平( OR值为1.20)均是该人群baPWV增高的独立危险因素( P<0.001)。交互作用分析，校正各因素(年龄、体重指数、收缩压、舒张压和规律运动)后高TyG指数和高ALP水平者出现baPWV增高的风险是TyG指数和ALP水平正常者的2.51倍(95% CI 2.01～3.14)，超额危险度(RERI)、归因危险度(AP)以及交互作用指数(SI)分别为2.825(1.255～3.905)，0.348(0.180～0.875)，1.657(0.628～3.374)。 结论:TyG指数和ALP水平是绝经后女性baPWV增高的独立危险因素，并且两者对该人群动脉僵硬度产生相加交互作用。

abstractsObjective:To investigate the effect of triglyceride-glucose(TyG) index and alkaline phosphatase(ALP) on brachial-ankle pulse wave conduction velocity(baPWV) in postmenopausal women.Methods:A cross-sectional study was conducted, enrolling 3 483 postmenopausal women who underwent health checkup at Taihu Sanatorium in Jiangsu Province from March 2020 to June 2021. The physical activity, body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, triglycerides, high-density lipoprotein-cholesterol(HDL-C), low-density lipoprotein-cholesterol(LDL-C), ALP, and baPWV were collected.Results:Age, body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, and LDL-C levels were significantly lower in the normal baPWV group( n=1 971) than those in the elevated baPWV group( n=1 512; P<0.001). Logistic regression identified the TyG index( OR=1.75) and ALP level( OR=1.20) as independent risk factors for elevated baPWV( P<0.001), besides with age, body mass index, systolic blood pressure, diastolic blood pressure, and regular exercise. Individuals with both high TyG index and elevated ALP had a 2.51-fold higher risk of elevated baPWV(95% CI 2.01-3.14). Adjusted interaction measures(including age, body mass index, systolic blood pressure, diastolic blood pressure, and regular exercise) showed RERI=2.825(95% CI 1.255-3.905), AP=0.348(95% CI 0.180-0.875), and SI=1.657(95% CI 0.628-3.374). Conclusions:The TyG index and ALP levels are independent risk factors for elevated baPWV in postmenopausal women and exhibit an additive interaction effect on arterial stiffness in this population.