摘要甲状腺危象是甲状腺功能亢进症(甲亢)患者可能遭遇的最严重并发症之一，在手术等应激情况下更易被诱发，术前甲状腺功能状态的准备对于甲亢患者具有重要意义，能够预防甲状腺危象的发生。近期Fazendin J研究团队在1篇纳入275例患者的回顾性队列研究的报道中提出，在甲状腺功能未达到正常状态、且不常规使用鲁氏碘液或抗甲状腺药物的情况下进行手术是安全的。该结论和推荐在医学界引起了广泛的讨论，本文旨在探讨甲亢手术治疗术前准备的相关策略及其争议，并回顾不同药物预防甲状腺危象的机制。

abstractsThyroid storm is one of the most severe complications that patients with hyperthyroidism may face, often triggered by surgery and other physiological stressors. Preoperative optimization of thyroid function is considered crucial in preventing thyroid storm. However, a recent cohort study of 275 patients, led by Fazendin J, suggested that surgery may be safely performed without achieving a euthyroid state beforehand or administering Lugol′s indine solution or antithyroid drugs. This conclusion has sparked considerable debate within the medical community. In this article, we examine current strategies for preoperative preparation in hyperthyroid surgery, explore ongoing controversies, and review the mechanisms by which various pharmacological interventions help prevent thyroid storm.