摘要目的:在上海长风社区45岁以上人群中比较不同代谢健康超重/肥胖（metabolically healthy overweight/obesity，MHO/O）标准，提出较为合理且适合我国人群的工作标准。方法:在上海长风社区45岁以上3 301例（男性1 521例，女性1 780例）超重/肥胖受试者中，根据目前7个不同的MHO/O标准，评估MHO/O检出率及检出率随体重指数（BMI）的变化趋势，并比较不同标准MHO/O的临床生化指标的差异。评估标准根据是否包含腰围、稳态模型法评估的胰岛素抵抗指数（HOMA-IR）≥2.5指标分为美国国家胆固醇教育计划成人治疗组Ⅲ（ATP-Ⅲ）标准（包括腰围）、ATP-Ⅲ标准（不包括腰围）、改良的代谢相关性脂肪肝病（MAFLD）标准，根据三类标准中代谢组分异常的数量（<1即含有0条，<2即含有0~1条，依次类推）进一步分为：ATP-Ⅲ（包括腰围）<1、ATP-Ⅲ（包括腰围）<2、ATP-Ⅲ（包括腰围）<3、ATP-Ⅲ（不包括腰围）<1、ATP-Ⅲ（不包括腰围）<2、改良的MAFLD标准<1、改良的MAFLD标准<2，共7个。结果:ATP-Ⅲ（包括腰围）<1、ATP-Ⅲ（包括腰围）<2、ATP-Ⅲ（包括腰围）<3、ATP-Ⅲ（不包括腰围）<1、ATP-Ⅲ（不包括腰围）<2、改良的MAFLD标准<1、改良的MAFLD标准<2的MHO/O检出率分别为2.85%、15.48%、39.87%、8.00%、33.66%、2.33%、12.24%。MHO/O检出率随BMI的升高而降低，当BMI≥28 kg/m 2时，ATP-Ⅲ（包括腰围）<1和改良的MAFLD标准<1标准的MHO/O检出率为均0。 结论:不含改良的MAFLD标准中异常组分的标准是较为合理的MHO/O判定标准。

abstractsObjective:To establish a more suitable and practicable criterion of metabolically healthy overweight/obesity (MHO/O) in Chinese, a comparison study on different criteria of MHO/O was conducted in subjects aged over 45-year-old in Shanghai Changfeng Community.Method:A total of 3 301 overweight/obese subjects over 45 years old (men 1 521, women 1 789) in Shanghai Changfeng Community was included in the study. According to the inclusion or exclusion of waist circumference (WC), homeostasis model assessment of insulin resistance (HOMA-IR) ≥2.5, and numbers of abnormal metabolic components, the MHO/O criteria were divided into 7 types: Adult Treatment Panel Ⅲ (ATP-Ⅲ) (with WC)<1 component, ATP-Ⅲ (with WC)<2 components, ATP-Ⅲ (with WC)<3 components, ATP-Ⅲ (without WC)<1 component, ATP-Ⅲ (without WC)<2 components, adjusted metabolic associated fatty liver disease (MAFLD) criteria<1 component, and adjusted MAFLD criteria<2 components. The prevalence of MHO/O and its relationship with the changes of body mass index (BMI), and the differences of the characteristics of MHO/O among the 7 types of metabolic health standards were compared.Result:The prevalence of MHO/O according to the ATP-Ⅲ (with WC)<1, ATP-Ⅲ (with WC)<2, ATP-Ⅲ (with WC)<3, ATP-Ⅲ (without WC)<1, ATP-Ⅲ (without WC)<2, adjusted MAFLD criteria<1, and adjusted MAFLD criteria<2 was 2.85%, 15.48%, 39.87%, 8.00%, 33.66%, 2.33%, 12.24%, respectively. The prevalence of MHO/O decreased as BMI increased. When BMI ≥ 28 kg/m 2, the prevalence of MHO/O by ATP-Ⅲ (with WC)<1 and adjusted MAFLD criteria<1 dropped to 0. Conclusion:The adjusted MAFLD criterion without abnormal metabolic components is the most practicable definition of MHO/O.