摘要患者男，25岁，因腹泻、血肌酐升高、血小板减少半年，再发1个月就诊。病初在新型冠状病毒感染后出现全身高炎症状态，伴有肾脏、消化系统、血液系统受累，糖皮质激素治疗一度有效，但在消化道感染后出现病情复发，合并反复脑梗死，最终经多学科团队协作，参考临床表现和淋巴结活检病理结果，诊断特发性多中心Castleman病（iMCD）-TAFRO综合征。之后经积极治疗原发病，原发病取得完全缓解。本例提示，病情复杂的iMCD-TAFRO综合征，需积极多学科紧密协作，尽早干预治疗，以取得更好的预后。

abstractsA 25-year-old male patient presented with diarrhea, elevated serum creatinine, and thrombocytopenia for six months, with a recurrence for one month. He developed a systemic hyperinflammatory state following SARS-CoV-2 infection, involving the renal, gastrointestinal, and hematologic systems. Although glucocorticoid therapy initially demonstrated efficacy, the patient experienced disease relapse post-gastrointestinal infection, complicated by recurrent cerebral infarctions. Through multidisciplinary collaboration and integrated assessment of clinical manifestations and lymph node biopsy pathology, a diagnosis of idiopathic multicentric Castleman disease (iMCD) with TAFRO syndrome was established. Following aggressive treatment targeting the primary disease, the patient achieved complete remission. This case illustrates that the complex clinical presentation of iMCD-TAFRO syndrome requires early intervention and rigorous multidisciplinary cooperation to improve patient prognosis.