摘要用牛脾转移因子口服液(OBS-TF)治疗异位性皮炎(AD)28例,井采用 3H放兔法测定了OBS-TF治疗前后AD患者及正常人血浆及外周血白细胞(PBL)中白三烯C 4(LTC 4)含量。AD血浆及PBL中LTC 4含量治疗前均明显高于正常人,治疗后则无显着差异,AD的严重程度与LTC 4水平相乎行,提示LTC 4可能作为强效炎症介质之一介入了AD的发病过程, OBS-TF则可能作为LTC 4的抑制剂对AD发挥了治疗作用。

abstractsUsing 3H radioimmunoassy, the levels of leukotriene C 4 (LTC 4) were determined in 25 atopic dermatitis (AD) patients before and after the treatment of oral bovine spleen transfer factor (OBS-TF) and 33 normal controls. The results revealed that the seventy of AD presented a positive correlation with the level of LAC 4, and the levels of LTC 4 in both plasma and peripheral blood leukocytes (PBL)in AD were markedly higher than those of normal donors (<i>P</i>&lt;0.001). The authors found that the OBS-TF could significantly reduce the levels of LTC 4 in both plasma and PBL, and significantly improve the symptoms and signs of AD. The results of our study indicated that LTC 4 may be involved in the pathogenetic process of AD as one of the strong inflammatory mediators, and OBS-TF may play an important role as an inhibitor of LTC 4 in AD.