摘要目的 探讨解脲脲原体生物群及基因型与女性非衣原体非淋球菌感染的黏液脓性宫颈炎的相关性.方法 女性非衣原体非淋球菌感染的黏液脓性宫颈炎患者及正常人群两组,对解脲脲原体培养阳性标本应用PCR-SSCP方法检测解脲脲原体的生物群及基因型.结果 解脲脲原体生物一群中的基因3/14型在两组中的检出率均最高,分别为30.98%(57/184)和43.42%(33/76).黏液脓性宫颈炎患者组中生物二群的解脲脲原体基因2B型的检出率为16.30%(30/184)明显高于正常人组的6.58%(5/76),差异有统计学意义(χ2=4.367,P=0.037).而健康体检组中主要以生物一群中的基因1、3/14、6型的单型别定植为主占81.58%.结论 解脲脲原体生物二群中的基因2B型可能与性病门诊就诊者中的非衣原体非淋球菌感染的黏液脓性宫颈炎有一定相关性.

abstractsObjective To study the association of U. urealyticum biovar and genotype with nongonococcal, nonchlamydial mucopurulent cervicitis. Methods The study population consisted of two groups: patient group (226 female patients with nongonococcal, nonchlamydial mucopurulent cervicitis) and control group (118 healthy women). The biovar and genotype of U. urealyticum were identified in specimens positive for U. urealyticum culture by using PCR-single-strand conformation polymorphism (PCR-SSCP) analysis. Results The most common genotype in both groups was mba 3/14 in biovar 1 with the detection rate being 30.98%(57/184) in patients with mucopurulent cervicitis and 43.42% (33/76) in the controls. A significant difference was observed in the prevalence of genotype 2B in biovar 2 between the patients and controls [16.30% (30/184) vs 6.58% (5/76), χ2 = 4.367, P= 0.037). The genotype 1, 3/14 and 6 in biovar 1 predominated in the controls with their total prevalence being 81.58%. Conclusion The genotype 2B in biovar 2 of U. urealyticum may be associated with nongonococcal, nonchlamydial mucopurulent cervicitis among female patients attending an STD clinic.