摘要大量证据表明精神因素如焦虑、紧张、精神应激等可以诱发或加重银屑病,还可以在一定程度上影响银屑病的治疗效果,提示精神因素可能在银屑病发病中起到重要作用.目前关于银屑病精神神经相关发病机制的研究主要体现在以下两方面,一方面精神因素作为应激源,引起下丘脑-垂体-肾上腺皮质轴与交感神经-肾上腺髓质系统两大神经内分泌系统的激活;另一方面神经肽及神经生长因子诱导体内的神经源性炎症反应.精神神经因素可能通过以上途径共同参与银屑病发病.

abstractsConsiderable evidence has indicated that psychological factors,such as anxiety,nervousness and mental stress,can induce or exacerbate psoriasis and affect therapeutic effects to a certain degree,suggesting that psychological factors may play an important role in the occurrence of psoriasis.Current researches on neuropsychiatry-related pathogenesis of psoriasis mainly include two aspects:on the one hand,acting as stressors,psychological factors can activate the following two neuroendocrine systems,including hypothalamic-pituitary-adrenocortical axis and sympathetic-adrenal medullary system;on the other hand,neuropeptides and nerve growth factors induce in vivo neurogenic inflammation.Neuropsychiatric factors may participate in the occurrence of psoriasis through the above pathways.