摘要目的 研究中国汉族儿童特应性皮炎(AD)疾病严重程度的影响因素,为儿童AD的防治提供科学依据.方法 利用2005年11月至2015年5月在安徽医科大学第一附属医院皮肤科及全国AD样本收集协作网收集的0～ 12岁AD患儿资料,通过SPSS16.0软件对影响AD疾病严重程度的相关因素进行单因素和有序Logistic回归分析.结果 2 620例AD患儿纳入研究,其中轻度230例(8.8％),中度1 379例(52.6％),重度1 011例(38.6％).单因素分析结果显示,地区、早年发病、出汗时瘙痒、干皮症、鱼鳞病、掌纹症、毛发苔藓、眶周黑晕、头皮皮炎、耳廓下裂隙对AD疾病严重程度影响显著(均P＜ 0.01).性别、有无个人或家庭特应史以及血清IgE水平有无增高组间AD疾病严重程度分布差异均无统计学意义(均P＞ 0.05).多因素有序Logistic回归分析结果表明,南方地区(OR=2.10,95％ CI:1.76～2.51)、早年发病(OR=1.32,95％ CI:1.01～1.71)、出汗时瘙痒(OR=1.70,95％CI:1.42～2.02)、干皮症(OR=2.57,95％CI:2.10～3.15)、鱼鳞病(OR=1.49,95％CI:1.19～1.87)、掌纹症(OR=2.03,95％ CI:1.61～2.57)、毛发苔藓(OR=1.44,95％ CI:1.17～1.78)、眶周黑晕(OR=1.53,95％ CI:1.24～1.89)、头皮皮炎(OR=2.38,95％ CI:2.01～2.82)、耳廓下裂隙(OR=1.55,95％CI:1.31～1.85)均与AD疾病严重程度呈正相关(均P＜0.05).结论 AD疾病严重程度与地域、早年发病和出汗时瘙痒、干皮症等伴发症状相关.

abstractsObjective To investigate factors influencing disease severity in children of Han nationality with atopic dermatitis (AD) in China,and to provide scientific evidences for prevention andtreatment of AD in children.Methods From November 2005 to May 2015,data were collected from AD children aged 0-12 years in Department of Dermatology,The First Affiliated Hospital of Anhui Medical University and AD sample collection collaboration network in China.Statistical analysis was carried out with SPSS16.0 software by using univariate and multivariate ordinal logistic regression analysis to investigate factors influencing the severity of AD.Results A total of 2 620 children with AD were enrolled into the study,including 230 (8.8％) with mild AD,1 379 (52.6％) with moderate AD and 1 011 (38.6％) with severe AD.As univariate analysis showed,factors influencing the severity of AD included region,early onset,itching during sweating,xeroderma,ichthyosis,palmar hyperlinearity,lichen pilaris,orbital darkening,scalp dermatitis and infra-auricular fissure (all P ＜ O.O1).There were no significant differences in the severity of AD between different genders,patients with and without personal or family atopic history,or between patients with and without a high serum IgE level (all P ＞ 0.05).Multivariate ordinal logistic regression analysis showed that southern region (OR =2.10,95％ CI:1.76-2.51),early onset (OR =1.32,95％ CI:1.01-1.71),itching during sweating (OR =1.70,95％ CI:1.42-2.02),xeroderma (OR =2.57,95％ CI:2.10-3.15),ichthyosis (OR =1.49,95％ CI:1.19-1.87),palmar hyperlinearity (OR =2.03,95％ CI:1.61-2.57),lichen pilaris (OR =1.44,95％ CI:1.17-1.78),orbital darkening (OR =1.53,95％ CI:1.24-1.89),scalp dermatitis (OR =2.38,95％ CI:2.01-2.82) and infra-auricular fissure (OR =1.55,95％ CI:1.31-1.85) were positively correlated with the severity of AD (all P ＜ 0.05).Conclusion The severity of AD is associated with patients' region,early onset,itching during sweating,xeroderma,and other concomitant symptoms.