摘要NLRP3炎性小体在固有免疫中发挥重要作用,通过活化胱天蛋白酶1诱导细胞因子白细胞介素(IL)-1β和IL-18的成熟和释放,参与多种宿主免疫和炎性反应.一旦机体对NLRP3炎性小体的调控失衡,则可能产生过量的IL-1β和IL-18,从而引发一系列炎症性疾病.NLRP3炎性小体活化在痤疮、银屑病、坏疽性脓皮病、多发性肌炎/皮肌炎、大疱性类天疱疮等皮肤病中发挥重要作用.本文综述NLRP3炎性小体在皮肤病中的研究进展.

abstractsNOD-like receptor protein 3 (NLRP3) inflammasomes play an important role in innate immunity.It can induce the maturation and release of cytokines interleukin (IL)-1β and IL-18 by activating caspase-1,and participate in a variety of host immunoinflammatory responses.Once the regulation of NLRP3 inflammasomes is unbalanced,excessive IL-1β and IL-18 may be produced,triggering a series of inflammatory diseases.NLRP3 inflammasome activation plays important roles in skin diseases such as acne,psoriasis,pyoderma gangrenosum,polymyositis/dermatomyositis and bullous pemphigoid.This review summarizes research progress in NLRP3 inflammasomes in skin diseases.