摘要目的:比较308 nm SQ LED光与308 nm准分子光治疗面部白癜风的治疗效果及安全性。方法:回顾分析2018年6月至2020年6月就诊于中国医学科学院皮肤病医院理疗科采用308 nm SQ LED光（LED组）或308 nm准分子光（准分子光组）治疗的稳定期面部白癜风患者。每周治疗1次或2次，纳入治疗8次以上的患者，分析其疗效及安全性。采用卡方检验进行统计学分析。结果:LED组纳入68例，男36例，女32例，年龄（25.01 ± 13.37）岁，90处皮损接受治疗；准分子光组纳入20例，男13例，女7例，年龄（27.15 ± 14.30）岁，28处皮损接受治疗。治疗8次、16次时LED组有效率（23.33%、46.67%）与准分子光组（14.29%、46.43%）差异均无统计学意义（ χ2 = 1.05、< 0.001，均 P > 0.05）。LED组36例（52.94%）出现持续性红斑，准分子光组有17例（85%）出现过持续性红斑或水疱，LED组治疗的不良反应发生率低于与准分子光组（ χ2 = 16.43， P < 0.001）。 结论:308 nm SQ LED光治疗面部白癜风与308 nm准分子光治疗同样有效，但安全性更好。

abstractsObjective:To compare efficacy and safety of 308-nm SQ light-emitting diode (LED) light versus 308-nm excimer light in the treatment of facial vitiligo.Methods:Patients with stable facial vitiligo were retrospectively collected from Department of Physical Therapy, Hospital of Dermatology, Chinese Academy of Medical Sciences from June 2018 to June 2020, who received treatment with 308-nm SQ LED light (LED group) or 308-nm excimer light (excimer light group). The treatment was performed once or twice a week, and patients who had received more than 8 sessions of treatment were included in the analysis of efficacy and safety. Statistical analysis was carried out by using chi-square test.Results:Totally, 68 patients with 90 lesions were enrolled into the LED group, including 36 males and 32 females, aged 25.01 ± 13.37 years; 20 patients with 28 lesions were enrolled into the excimer light group, including 13 males and 7 females, aged 27.15 ± 14.30 years. After 8 and 16 sessions of treatment, there was no significant difference in the response rate between the LED group (23.33%, 46.67%, respectively) and excimer light group (14.29%, 46.43%, χ2 = 1.05, < 0.001, respectively, both P > 0.05). During the treatment, 36 (52.94%) patients in the LED group developed persistent erythema, 17 (85%) in the excimer light group developed persistent erythema or blisters. The incidence of adverse reactions was significantly lower in the LED group than in the excimer light group ( χ2 = 16.43, P < 0.001) . Conclusion:Compared with the 308-nm excimer light, the 308-nm SQ LED light showed similar effect but higher safety for the treatment of facial vitiligo.