摘要目的:分析白癜风光疗复色模式的影响因素。方法:回顾性收集2013年6月至2022年5月于空军军医大学西京皮肤医院接受308 nm准分子激光或308 nm准分子光治疗的白癜风患者临床资料，治疗频率为3次/周，每治疗5次根据临床皮损照片评估。采用 χ2检验或Fisher确切概率法分析不同临床特征与白癜风复色模式之间的关联。 结果:共纳入223例白癜风患者，包括男109例（48.9%），女114例（51.1%），年龄[ M（ Q1， Q3）]为20（10，28）岁。170例（76.2%）采用308 nm准分子激光治疗，53例（23.8%）采用308 nm准分子光治疗。所有病例复色模式为毛囊周围型63例（28.3%），皮损边缘型97例（43.5%），弥漫型36例（16.1%），混合型27例（12.1%）。分析不同临床特征与白癜风复色模式之间的关联显示，不同性别和不同Fitzpatrick皮肤分型的白癜风患者复色模式差异无统计学意义（均 P > 0.05）；≤ 12岁的儿童患者（ χ2 = 7.71， P = 0.005）、进展期患者（ χ2 = 4.59， P = 0.030）和未伴发白色毛发的皮损区域（ χ2 = 6.75， P = 0.009）更容易发生弥漫型复色模式；节段型白癜风患者更容易发生混合型复色模式（ χ2 = 11.76， P = 0.001）；面颈部（ χ2 = 15.82， P<0.001）和肢端（ χ2 = 11.85， P = 0.001）皮损更容易发生边缘型复色模式；稳定期患者（ χ2 = 4.70， P = 0.030）、躯干皮损较面颈部（ χ2 = 13.73， P<0.001）和肢端（ χ2 = 5.49， P = 0.035）更容易发生毛囊周围型复色模式；在308 nm准分子激光治疗后出现皮损边缘型复色（ χ2 = 12.30， P<0.001）和弥漫型复色（ χ2 = 5.64， P = 0.018）的比例更高，而308 nm准分子光治疗后出现毛囊周围型复色（ χ2 = 7.87， P = 0.005）和混合型复色（ χ2 = 17.13， P<0.001）的比例更高。 结论:白癜风患者的年龄、临床分型、临床分期、伴发白色毛发情况、皮损部位、光疗方式是白癜风复色模式的影响因素。

abstractsObjective:To analyze factors influencing repigmentation patterns in patients with vitiligo treated with phototherapy.Methods:Clinical data were retrospectively collected from patients with vitiligo treated with 308-nm excimer laser or 308-nm excimer lamp at the Department of Dermatology, Xijing Hospital, Air Force Medical University from June 2013 to May 2022. The treatment frequency was thrice weekly, and skin lesions were evaluated via photographs once every 5 sessions of phototherapy. Chi-square test or Fisher′s exact test was used to analyze associations between clinical characteristics and vitiligo repigmentation patterns.Results:A total of 223 patients with vitiligo were included in this study, including 109 males (48.9%) and 114 females (51.1%), and their ages ( M [ Q1, Q3]) were 20 (10, 28) years. Among the 223 patients, 170 (76.2%) were treated with 308-nm excimer laser, and 53 (23.8%) with 308-nm excimer lamp. The repigmentation patterns included the perifollicular pattern in 63 cases (28.3%), marginal pattern in 97 (43.5%), diffuse pattern in 36 (16.1%), and mixed pattern in 27 (12.1%). Analysis of the associations between clinical characteristics and vitiligo repigmentation patterns showed no significant differences in the repigmentation patterns among vitiligo patients of different genders or different Fitzpatrick skin types (both P > 0.05) ; however, the diffuse repigmentation pattern more frequently occurred in the patients aged ≤ 12 years compared with those aged > 12 years ( χ2 = 7.71, P = 0.005), in the patients with vitiligo in the progressive stage compared with those in the stable stage ( χ2 = 4.59, P = 0.030), and in lesions without white hair compared with those with white hair ( χ2 = 6.75, P = 0.009) ; the mixed repigmentation pattern more frequently occurred in the patients with segmental vitiligo compared with those with non-segmental vitiligo ( χ2 = 11.76, P = 0.001) ; the marginal repigmentation pattern more frequently occurred in lesions on the face and neck ( χ2 = 15.82, P<0.001) and extremities ( χ2 = 11.85, P = 0.001) compared with lesions on the trunk; the perifollicular repigmentation pattern more frequently occurred in the patients with stable vitiligo compared with those with progressive vitiligo ( χ2 = 4.70, P = 0.030), and in skin lesions on the trunk compared with those on face and neck ( χ2 = 13.73, P < 0.001) and extremities ( χ2 = 5.49, P = 0.035) ; after 308-nm excimer laser treatment, the proportions of patients with the marginal repigmentation pattern ( χ2 = 12.30, P < 0.001) and those with the diffuse repigmentation pattern ( χ2 = 5.64, P = 0.018) were significantly higher than those after 308-nm excimer lamp treatment, while the proportions of patients with the perifollicular repigmentation pattern ( χ2 = 7.87, P = 0.005) and those with the mixed repigmentation pattern ( χ2 = 17.13, P < 0.001) were significantly higher after 308-nm excimer lamp treatment than those after 308-nm excimer laser treatment. Conclusion:Patients′ age, clinical types and stages of vitiligo, presence or absence of concomitant white hair, skin lesion sites, and phototherapy modalities were factors influencing the repigmentation patterns of vitiligo.