摘要目的 探讨下肢深静脉血栓形成后遗症(postphlebitic syndrome,PS)的相关危险因素.方法 选择非手术治疗的下肢深静脉血栓形成(deep vein thrombosis,DVT)患者102例,对年龄、性别、病因、抗凝治疗、发病性质、弹力循环袜治疗、下肢锻炼等级、国际标准化比值(international normalized ratio,INR)、白细胞(white blood cells,WBC)、凝血酶原时间(prothrombin time,PT)PT%、血液纤维蛋白原含量(fibrinogen,FIB)进行单因素和多因素分析(COX回归模型分析).结果 PS发生率为67.6%(69/102),单因素分析显示性别(P=0.025)、抗凝治疗(P=0.000)、弹力循环袜治疗(P=0.000)、下肢锻炼等级(P=0.000)、INR(P=0.033)、WBC(P=0.012)等因素发生率差异有统计学意义.PT%(P=0.000),FIB(P=0.002)两因素内不同组别间发生率差异有统计学意义,多因素分析显示抗凝治疗(P=0.011)、下肢锻炼等级(P=0.019),弹力循环袜治疗(P=0.000)不同组别间发生率差异有统计学意义.年龄(P=0.299)、病因(P=0.838)及发病急慢(P=0.217)的不同组别间PS发生率差异无统计学意义. 结论是否完成弹力循环袜治疗和抗凝治疗以及下肢锻炼等级是决定PS的独立预后因素.

abstractsObjective To assess the risk factors of postphlebitic syndrome(PS)after deep vein thrombosis of the lower extremities. Method In this study,102 DVT patients managed by conservative therapy were recruited.Data including age,sex,etiopathogenesis,anticoagulation,pathogenesis, elasticstocking therapy,degree of lower extremity exercise,INR,WBC,PT%and FIB were analyzed by single factor analysis and COX analysis. Result PS developed in 67.60%cases,single factor analysis shows:sex(P=0.025),anticoagulation(P=0.000),elastic-stocking therapy(P=0.000),degree of lower extremity exercises(P=0.000),INR(P=0.033),WBC(P=0.012),PT%(P=0.000),FIB(P=0.002)are related to the occurrence of PS.COX regression shows that anticoagulation(P=0.011),the degree of lower extremity exercise(P=0.019),elastic-stocking therapy(P=0.000)are related to PS.Age (P=0.299),etiopathogenisis(P=0.838)and pathogenesis(P=0.2 17)are not statistically PS related.Conclusion DVT is a multi-factors related disease.Multivariant analysis revealed that elastic-stocking (P=0.000),anticoagulation(P=0.011)and the degree of lower extremity exercises(P=0.019)are related to the development of PS.