摘要目的 探讨乳腺癌前哨淋巴结微小转移与孤立肿瘤细胞转移的临床意义及其治疗方法.方法 回顾性分析2013年1月至2015年12月中国医学科学院肿瘤医院97例乳腺癌前哨淋巴结微小转移与孤立肿瘤细胞转移病例的临床资料及随访结果,根据腋窝手术方式分为腋窝淋巴结清扫组(41例)与腋窝淋巴结非清扫组(56例),比较两组间总生存率与无病生存率差异.结果 两组病例在年龄、原发灶大小、病理分级、激素受体状态、HER2基因表达、Ki-67水平、微转移灶大小、乳房手术方式、术后辅助性化疗、放疗、内分泌治疗比例等方面差异均无统计学意义(均P ＞0.05).术后共96例患者获得随访,中位随访时间24个月,腋窝淋巴结清扫组与非清扫组无病生存率分别为97.5％与96.6％;总生存率分别为100％与98.2％,差异均无统计学意义(均P＞0.05).淋巴结非清扫组术后2例(3.6％)发生同侧腋窝淋巴结复发,淋巴结清扫组无腋窝淋巴结复发.结论 乳腺癌前哨淋巴结微小转移与孤立肿瘤细胞转移患者可免于腋窝淋巴结清扫手术,但应加强术后系统性辅助治疗.

abstractsObjective To explore the clinical significance and treatment regimen of sentinel lymph node(SLN) micrometastases and isolated tumor cell metastasis in breast cancer.Methods Ninety-seven breast cancer patients with sentinel lymph node micrometastases or isolated tumor cell metastasis from January 2013 to December 2015 were retrospectively studied.The patients were assigned to axillary lymph node dissection group (ALND,41 cases) and non axillary lymph node dissection group(non-ALND,56 cases) according to the final surgery mode to the axilla.Disease-free survival(DFS) and overall survival (OS) were compared between the two groups.Results Neither clinico-pathological factors,such as age,tumor size,grade,ER/PR status,HER-2 gene expression,Ki-67 expression and the size of the SLN metastasis,nor the treatment,such as breast surgery,postoperative adjuvant chemotherapy,radiotherapy and hormone therapy were found statistically different between the two groups (P ＞ 0.05).There were 96 patients evaluable with a median follow up of 24 months.The DFS of the ALND and non-ALND group was 97.5％ and 96.6％ (P ＞ 0.05),and the OS was 100％ and 98.2％ (P ＞ 0.05) respectively with no difference between the two groups.There were 2 ispilateral axillary recurrence in the non-ALND group and non in the ALND group.Conclusion Axillary lymph node dissection may be omitted for the breast cancer patients with sentinel lymph node micrometastases and isolated tumor cell metastases.But the postoperative adjuvant systemic treatment should be emphasized.