摘要目的 探讨化疗相关血清碱性磷酸酶(alkaline phosphatase,ALP)升高对胃癌根治术后患者无瘤生存时间(tumor-free survival,TFS)的影响.方法 收集2010年1月至2015年12月在解放军第三○九医院普通外科接受根治性手术以及术后辅助化疗的189例胃癌患者的临床资料,采用单因素和多因素方法进行统计分析.结果 血清ALP升高胃癌患者的TFS较ALP正常胃癌患者缩短(x2=5.717,P=0.017).血清ALP升高是胃癌患者TFS的独立危险因素(HR=2.178,P=0.032).血清ALP升高的程度与TFS有关(x2=4.627,P=0.031).结论 化疗期间出现血清ALP升高提示胃癌根治术后患者复发转移的风险增加.

abstractsObjective To identify the influence of chemotherapy-induced serum alkaline phosphatase (ALP) elevation on the tumor-free survival (TFS) in patients of gastric carcinoma after radical gastrectomy.Methods The clinical data of 189 gastric carcinoma patients receiving radical surgery and postoperative adjuvant chemotherapy between Jan,2010 and Dec,2015 were reviewed and statistically analyzed.Results The TFS of patients with serum ALP elevation was obviously inferior than those without ALP elevation (x2 =5.717,P =0.017),serum ALP elevation was an independent risk factor influencing patients' TFS (HR =2.178,P =0.032),the degree of serum ALP elevation was associated with patients' TFS (x2 =4.627,P =0.031).Conclusion Serum ALP elevation during postoperative chemotherapy indicates the increases of recurrence or metastasis rate of gastric cancer patients after radical gastrectomy.