摘要目的:分析幽门螺杆菌（ H. pylori）家庭内感染状况及传播特点。 方法:本研究为横断面调查。2020年9月至2021年3月，随机分层选择郑州市9个不同社区266个家庭进行问卷调查，同时对所有家庭成员行 H. pylori抗体血清学检测，对既往已根除人群进行 13C-尿素呼气试验，明确其现症感染情况，分析家庭总体感染情况，菌株分布情况，父母、子女及夫妻关系的成员感染情况。 结果:266个家庭共731人， H.pylori阳性者397人，个体感染率为54.31%（397/731）。Ⅰ型菌株感染占77.83%（307/397），Ⅱ型菌株感染占22.67%（90/397）。 H.pylori阳性组和阴性组家庭年收入差异无统计学意义（ χ2=0.419、0.410、0.213，均 P>0.05），吸烟史（ χ2=0.071）、饮酒史（ χ2=0.071）、就餐地点（ χ2=0.009）、胃肠道症状（ χ2=0.047）、胃病家族史（ χ2=0.069）及胃癌病史率（ χ2=0.004）差异均无统计学意义（均 P>0.05），但受教育程度较高的个体感染率较低（ χ2=4.449， P<0.05）。18岁以上各年龄组感染率均明显高于≤18岁组（ χ2=6.531、23.362、20.671、24.244、37.948、14.597、5.170，均 P<0.05）。266个家庭中，家庭感染率为87.59%（233/266），其中有61个家庭全部成员均感染（26.18%，61/233）。子女年龄<18岁的家庭共50个，双亲均有 H. pylori感染时，子女阳性率为23.08%（6/26）。231个夫妻双方共同生活的家庭中，夫妻双方均感染的家庭78个（33.76%），夫妻双方均未感染的家庭40个（17.32%），夫妻双方仅一方感染的家庭113个（48.92%）。随着婚姻持续年份的增加，夫妻双方的感染率都大幅上升（ χ2=7.775、12.662、15.487，均 P<0.05）。 结论:郑州地区 H. pylori家庭感染情况较为严重，Ⅰ型 H. pylori感染是本地区的主要感染菌株。家庭内传播是 H. pylori感染的重要途径。

abstractsObjective:To investigate Helicobactor pylori (H. pylori) infection status and interfamilial transmission pattern in Zhengzhou area. Methods:A cross-sectional study was conducted from September 2020 to march 2021, among 731 individual from 266 families randomly selected from 9 communities of Zhengzhou area. H. pylori infection status was determined by serum antibody tests, and 13C-urea breath test was performed in the previously eradicated population to clarify the current infection status. The individual and familial infection rate, infection status for couples and children and adolescent were analyzed. Results:Among 731 individuals from 266 families, 397 of them were H. pylori positive. The individual infection rate was 54.31% (397/731); among infected individuals 77.83% (307/397) were infected with type Ⅰ strain, 22.67% (90/397) were infected by type Ⅱ strain. Annual household income ( χ2=0.419, 0.410, 0.213, all P>0.05), smoking history (χ 2=0.071, P>0.05), drinking history ( χ2=0.071, P>0.05), dining place ( χ2=0.009, P>0.05), gastrointestinal symptoms ( χ2=0.047, P>0.05), family history of gastric disease ( χ2=0.069, P>0.05), and history of gastric cancer ( χ2=0.004, P>0.05) had no significant differences between H. pylori-positive and -negative groups, but the infection rate in individuals with higher education level was lower ( χ2=4.449, P<0.05). The infection rate was significantly higher in≥18 age groups compared with<18 age groups ( χ2=6.531, 23.362, 20.671, 24.244, 37.948, 14.597 and 5.170, all P<0.05). The familial H. pylori infection rate was 87.59% (233/266), and in 61 families all member were infected (26.18%, 61/233). The positive rate was 23.08% (6/26) in 50 families with children under 18 years when both parents were infected. Among 231 coupled families, both couples were infected in 78 families (33.76%), one couple was infected in 113 families (48.92%), and both couples were not infected in 40 (17.32%). With the increase of marriage time, the infection rate of both spouses increased significantly ( χ2=7.775, 12.662, 15.487, all P<0.05). Conclusions:The distribution of H. pylori infection presents a family cluster pattern, and intrafamilial infection is an important transmission rout of H. pylori. The type I strain of H. pylori is the dominate strain in this area.