摘要Objectives:The Advanced Lung Cancer Inflammatory index(ALI)has been established as a reliable prognostic marker for cardiovascular and cerebrovascular diseases.However,the relationship between ALI and outcome in acute ischemic stroke(AIS)patients treated with intravenous thrombolysis(IVT)remains unclear.Methods:This study enrolled 784?AIS patients treated with IVT all of whom were followed up for at least 3?months after treatment.3-month post-thrombolysis non-excellent outcome was defined as the modified Rankin Scale ranging from 2 to 6.The research investigated the relationship between ALI and non-excellent outcome in AIS patients treated with IVT,via multivariate logistic models and restricted cubic spline(RCS)analyses,etc.Results:When the patients were divided into four quartiles(Q)based on ALI levels,we found that those with lower ALI levels were more likely to experience non-excellent outcome(P<0.001).The multivariate logistic model revealed that reduced ALI levels(odds ratio[OR]:0.487,95%confidence interval[CI]:0.310-0.767,P?=?0.002)were significant associated with non-excellent outcomes(ALI Q4?vs.Q1)after the adjustment of confounding factors.RCS analyses exhibited a non-linear J-shaped pattern(Poverall?=?0.003,Pnonlinear?=?0.013).Conclusion:Decreased levels of ALI might be associated with post-thrombolysis non-excellent outcome in AIS patients.