摘要目的 探讨安钠咖相关脑损害的临床表现及磁共振成像(MRI)特征.方法 对3例安钠咖相关脑损害患者进行临床及MRI观察.结果 3例均为男性,均有明确的烫吸安钠咖史(烫吸时间3～7年),除具有反应迟钝、智力障碍等常见的中毒性脑病特征外,尚有特殊的语言及肌张力障碍;头颅MRI显示双侧对称性大脑半球、内囊后肢、胼胝体、双侧大脑脚、脑桥的广泛脱髓鞘改变.3例经皮质激素、神经营养等治疗,在病后40 d病情均明显好转,仅例1残留轻度情感控制障碍.结论 安钠咖相关脑损害有特殊的语言及肌张力障碍,MRI存在广泛脱髓鞘,了解这些特点可为预防和治疗安钠咖引起的并发症提供帮助.

abstractsObjective To study the clinical manifestation and MRI feature of toxic encephalopathy after inhaling caffeine and sodium benzoate. Methods Three patients with toxic encephalopathy induced by inhaling caffeine and sodium benzoate were observed clinically and with MRI. Results The 3 patients were male. They all had definite addiction histories (the time of addiction for 3 years to 7 years ). There were special language and retropulsive dystonia besides the common characteristics of toxic encephalopathy:reaction retardation and disturbance of intelligence. MRI showed the change of generalized demyelination in bilateral symmetrical cerebral hemisphere, posterior limbs of internal capsule, corpus callosum, medial lemniscus, and cerebellum hemisphere dentate nucleus. The clinical symptoms of 3 patients were significantly improved 40 days after the adrenocortical steroid and neurotrophic treatment. The mild mood disorder remained in case 1. Conclusion Clinical manifestation and MRI of toxic encephalopathy after inhaling caffeine and sodium benzoate are known, so we could diagnose the patients of the disease in time.