摘要目的 采用单光子发射计算机断层显像(SPECT)局部脑血流(rCBF)半定量分析法,观察改良强制性运动疗法(mCIMT)对老年脑梗死偏瘫患者肢体运动功能的康复疗效.方法 12例符合入选标准的患者,男性7例,女性5例,年龄61～79(67.9±6.5)岁,病程21～77(42.7±13.6)d.进行8周的改良强制性运动疗法治疗,不限制健侧上、下肢活动,每天保持4 h的患侧上、下肢训练,其中上肢1 h,下肢3 h.在治疗前后分别进行简易手功能检查法(STEF)、10 m最大步行速度(MWS)和大脑皮质缺血灶rCBF评估.结果 治疗后STEF患侧评分为76.33±17.13(t=-6.09),STEF健侧评分为86.25 ±16.84(t=-5.86);MWS评分为6.78±3.72(t=4.88);缺血区放射性计数评分为-10.12 ± 7.25(t=5.33),明显优于治疗前,差异有统计学意义(均P＜0.05).结论 使用SPECT技术观察发现,改良强制性运动疗法明显提高老年脑梗死患者肢体运动功能,证明这种变化与大脑可塑性改变相关联,推测可能与大脑皮质rCBF重新分配有关.

abstractsObjective To observe the correlation of brain functional reorganization and motor functional restoration with application of single-photon emission computed tomography (SPECT) and regional cerebral blood flow ( rCBF) in modified constraint-induced movement therapy ( mCIMT) in cerebral infarction patients with hemiplegia.Methods Twelve patients with cerebral infarction with hemiplegia (7 males and 5 females, aged 62-75 ( 67.9 ± 6.5) years) were treated with mCIMT for eight weeks.No movement restriction was applied to the limbs at the intact sides.The affected sides exercised 4 h per day with 1 h on the upper limbs and 3 h on the lower limbs.At the same time, semi-quantitative analysis method of analyzing SPECT and rCBF was used to record changes in brain.Simple test for evaluating hand function (STEF), 10 m maximum walking speed ( MWS) , rCBF changes in the cerebral cortex ischemic lesion were respectively assessed in the pretreatment and post-treatment.Results After the treatment, STEF score of affected sides was 76.33 ± 17.13(t = -6.09) ; STEF score of intact was 86.25 ± 16.84(t = -5.86) ;The score of MWS was 6.78 ± 3.72 (t = 4.88); Ischemic score of radioactive counts was - 10.12 ± 7.25 (t = 5.33), improved from pre-treatment and the difference was statistically significant (all P ＜ 0.05 ) .Conclusions mCIMT markedly improved motor function in senile cerebral infarction patients with hemiplegia as shown on SPECT.It showed that this improvement is associated with changes in brain plasticity, suggesting that improved motor function may be related to the redistribution of regional cerebral blood flow in the cerebral cortex.