摘要目的 探讨慢性失眠对记忆的影响.方法 选取55例原发性失眠(PI)患者、119例抑郁伴发失眠(CDI)患者和50名健康对照者(对照组),采用九盒迷宫进行客观记忆(空间工作和空间参考记忆、物体工作和物体参考记忆)检测,按0(很差)～4(很好)5个等级让受试者自我评定记忆.结果 与对照组相比,PI患者轻度时记忆自评[四分位数间距,记忆自评单位为等级,其他指标均为错误数,3(2,3)与1(1,2)]和重度时空间工作记忆[3(1,5)与6(2.5,11)]差(×2=4.526、3.529,均P＜0.01).CDI患者轻度时记忆自评[2(1,2)]和空间工作记忆[6(3,10)]差(×2=5.803、4.155,均P＜0.01),重度时物体参考[0.5(0,1)]和空间参考记忆[1.5(1,3)]也变差(×2=2.641、3.955,均P＜0.01).结论 PI损害主观记忆,严重时损害空间工作记忆.CDI损害记忆范围更广,包括主观、物体参考、空间参考和空间工作记忆.

abstractsObjective To explore memory function affected by chronic insomnia. Methods Fiftyfive patients with primary insomnia (PI), 119 patients with comorbidity of depression and insomnia (CDI)and 50 normal individuals were enrolled. Objective memories, including spatial working memory, spatial reference memory, objective working memory and object reference memory, were detected by nine boxes maze, and subjective memory was assessed by themselves on a 5-point scale ranging from "0" ( extremely severe problem) to "4" (no problem). Results Compared to the controls, the self-evaluated memory ( 1( 1,2 ) ) was worse in the mild PI patients, and the spatial working memory ( 6 ( 2. 5,11 ) ) was also worse in the severe PI patients( ×2 = 4. 526,3. 529, both P ＜ 0. 01 ). For the CDI, the self-evaluated memory ( 2 ( 1,2) ) and spatial working memory (6(3,10)) were worse in the mild patients(×2 =5. 803,4. 155 ,both P ＜0. 01 ). However, the object ( 0. 5 (0,1) ) and spatial reference ( 1.5 ( 1, 3 ) ) memories were also worse in the severe patients ( ×2 =2. 641,3. 955 ,both P ＜0. 01 ). Conclusions PI damages subjective memory and the severe PI also damages spatial working memory. CDI damages various memory functions, especially in severe CDI patients, including subjective memory, object reference memory, spatial reference memory and spatial working memory.