摘要目的 利用默念产词任务研究颞叶癫痫患者与健康对照语言网络的差异性,从而揭示颞叶癫痫患者涉及语言功能区域的核心节点.方法 共纳入32例颞叶癫痫患者和32名性别和年龄相匹配的健康对照.所有受试者在默念产词任务下扫描功能磁共振数据.利用MATLAB平台SPM8软件对数据进行处理.采用条件Granger因果检验方法研究颞叶癫痫患者语言网络节点之间的因果关系.结果 与健康对照相比,颞叶癫痫患者产词任务时激活增强区域包括右侧后扣带回和右侧楔前回,未发现激活降低的区域.条件Granger因果检验分析发现,患者组在左侧楔前回到左侧岛叶,左侧岛叶到左侧后扣带回以及左侧额中回到右侧岛叶的单向条件Granger因果连接增加.结论 岛叶、后扣带回均参与了颞叶癫痫患者语言网络,可能为语言网络重组以及大脑可塑性提供了影像学证据.

abstractsObjective Temporal lobe epilepsy (TLE) patients often have language impairment.The present study is to examine the effective connectivity within the language network in TLE patients by analyzing functional magnetic resonance imaging (fMRI) while performing a silent verb generation task.Methods Thirty-two TLE patients and thirty-two healthy controls were recruited in the study.The fMRI was recorded while the subjects performing verb-generation task.The brain imaging data were analyzed using MATLAB-SPM8 mapping program.The correlation of the connectivities within the language network was analyzed by means of Granger causality.Results Compared to the controls,the activated areas in TLE patients are mainly located in right posterior cingulate gyrus and right precuneus.Granger causality mapping implied a possible correlation between left precuneus and left insular,left insular and left posterior cingulate gyrus,and between left medial frontal gyrus and right insular.Conclusion Granger causality analysis suggests insular,posterior cingulate gyrus may involve in the effective reorganization of language network in TLE patients,which provides the neuroimaging marker for plasticity of brain.