摘要目的 研究帕金森病初诊患者情感淡漠及其神经心理学特点.方法 将82例帕金森病初诊患者和30名年龄、性别、教育程度相匹配的健康对照者纳入研究.应用淡漠评估量表(AES)评定情感淡漠,同时分析患者的年龄、性别、教育年限和病程.应用统一帕金森病评定量表(UPDRS)、汉密尔顿抑郁量表(HAMD)和蒙特利尔认知评估量表(MoCA)分别评定患者的运动、抑郁和认知功能.结果 帕金森病患者的情感淡漠得分明显高于健康对照组.帕金森病患者中,情感淡漠的发生率为51.2％ (42/82),抑郁的发生率为19.5％ (16/82).帕金森病情感淡漠组(n=42)和非淡漠组(n=40)在年龄、性别、教育年限、病程、UPDRSⅡ/Ⅲ得分、MoCA得分之间差异无统计学意义(均P ＞0.05),两组间HAMD得分差异有统计学意义[情感淡漠组的HAMD得分为(10.61±3.3)分,非情感淡漠组的HAMD得分为(5.96±1.9)分,t=7.87,P＜0.05].相关分析显示AES得分与年龄、教育年限、病程、UPDRSⅡ/Ⅲ得分均无相关性(均P＞0.05),与HAMD得分呈正相关(r=0.244,P =0.007).结论 在帕金森病初诊患者中,情感淡漠独立于抑郁、运动功能障碍和认知功能损害而存在,可能是帕金森病的早期信号.

abstractsObjective To investigate the apathy and neuropsychological characteristics of newly diagnosed Parkinson's disease (PD) patients.Methods Eighty-two newly diagnosed PD patients and 30 matched healthy controls by age,sex and education level were recruited in the present study.Apathy was assessed using Apathy Evaluation Scale (AES) and related factors,including age,sex,education level and disease duration were simultaneously evaluated.Unified Parkinson's Disease Rating Scale (UPDRS),Hamilton Depression Rating Scale (HAMD),as well as Montreal Cognitive Assessment (MoCA) were employed in order to respectively evaluate the motor function,depression and cognition.Results The AES scores in the PD patients were significantly higher when compared to the healthy controls.The prevalence of apathy and depression in the PD patients was 51.2％ (42/82) and 19.5％ (16/82),respectively.There were no statistically significant differences in age,sex,education level,UPDRS-Ⅱ/Ⅲ scores and MoCA scores between apathy (n =42) and no-apathy (n =40) PD patients (P ＞ 0.05),while the statistically significant difference in HAMD scores between apathy (n =42) and no-apathy (n =40) PD patients was shown (the HAMD scores of apathy PD patients were 10.61 ± 3.30,the HAMD scores of no-apathy PD patients were 5.96 ± 1.90,t =7.87,P ＜ 0.05).The correlation analysis indicated that there were no correlations between AES scores and the related factors,including age,education level,disease duration and UPDRS-Ⅱ / Ⅲ scores,but AES scores were positively correlated with HAMD scores.Conclusion In newly diagnosed PD patients,the apathy is independent of depression,motor dysfunction,as well as cognitive impairment,which may be an early signal for PD.