换一批
换一批摘要阿尔茨海默病(AD)是一种慢性进行性的神经变性疾病,其发病机制尚未完全阐明,目前也缺乏能够改变疾病结局的药物.疱疹病毒感染假说萌生已久,但由于缺乏有力证据,与经典的β淀粉样蛋白瀑布假说相比,该假说一直备受争议.新近的研究为假说提供了新的证据支持,但争议依然存在,本文将对此进行评述,以期为AD临床干预提供新思路.
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abstractsAlzheimer's disease is a chronic progressive neurodegeneration disease,currently the pathogenesis of which is not fully elucidated and no disease-modifying therapies are available.The amyloid-beta cascade hypothesis is still predominant in the field.Although has been proposed for decades,the herpes virus hypothesis remains controversial due to lack of solid evidence.New evidence supporting the hypothesis is emerging while debates remain,which would be the focus of this paper.
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主题词
阿尔茨海默病(Alzheimer Disease)疱疹病毒科感染(Herpesviridae Infections)疱疹病毒科(Herpesviridae)蛋白(Egg White)性(Sex)
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专论
DOI
10.3760/cma.j.issn.1006-7876.2019.03.001
发布时间
2019-04-26
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