摘要帕金森病是以异常α-突触核蛋白沉积为特征的神经系统变性疾病,临床主要表现为运动障碍.随着研究的深入,帕金森病非运动症状逐渐被认识,其中尿频尿急等泌尿系统症状严重影响患者的生活质量.帕金森病泌尿系症状还反映大脑中的病变,例如前额叶黑质纹状体D1多巴胺能膀胱抑制通路.故对其早期诊断和治疗至关重要.文中将综述帕金森病泌尿系统功能障碍研究进展.

abstractsParkinson's disease is a neurodegenerative disease characterized by abnormal α-synuclein deposition.The main clinical manifestation is dyskinesia.With the deepening of research,the non-motor symptoms of Parkinson's disease are gradually recognized,and the urinary symptoms such as daytime frequency and urinary urgency affect the quality of patients' life.Urinary symptoms of Parkinson's disease also reflect the lesions in the brain,such as the D1 dopaminergic bladder inhibitory pathway of the prefrontal nigrostriatal tract.Therefore,its early diagnosis and treatment is essential.This article reviews the progress of urinary dysfunction in Parkinson's disease.