左乙拉西坦改善颞叶癫痫认知功能障碍的研究进展
Research progress of the improvement of cognitive dysfunction in temporal lobe epilepsy by levetiracetam
摘要颞叶癫痫是最常见的难治性局灶性癫痫,多数患者具有显著的认知功能障碍。癫痫发作不仅会引起认知功能障碍,而且许多抗癫痫药物会对认知造成不良影响。因此,选择合适的抗癫痫药物对颞叶癫痫患者的预后具有十分重要的意义。目前有研究结果提示左乙拉西坦(levetiracetam,LEV)对癫痫的认知功能具有改善作用,但对颞叶癫痫认知功能障碍的影响及作用机制目前尚未完全明了。文中就LEV改善颞叶癫痫认知功能障碍的研究进行综述。
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abstractsTemporal lobe epilepsy is the most common refractory focal epilepsy and most patients have significant cognitive dysfunction. Not only can seizures cause cognitive impairment, but also many antiepileptic drugs can have adverse effects on cognition. So, it is very important to choose appropriate antiepileptic drugs for the prognosis of temporal lobe epilepsy patients. At present, some studies suggest that levetiracetam (LEV) can improve the cognitive function of temporal lobe epilepsy. However, the effect and mechanism of cognitive dysfunction in temporal lobe epilepsy is not yet fully understood, so this review will focus on the effects of LEV on the cognitive dysfunction of temporal lobe epilepsy.
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