脊髓蛛网膜下腔植入Ommaya囊注射诺西那生治疗脊髓性肌萎缩2型患者1例
Intrathecal delivery of nusinersen using the Ommaya reservoir in a spinal muscular atrophy type 2 patient: a case report
摘要Ommaya囊植入术在神经外科常用于治疗脑积水以及脑室内给药,脊髓蛛网膜下腔植入Ommaya囊进行鞘内注射给药目前国内尚未开展,检索国外文献仅有少量报道。60%~90%未经治疗并存活到成人时期的脊髓性肌萎缩2型(SMA2型)患者往往伴有复杂的脊柱侧弯和关节畸形。诺西那生是治疗SMA2型的有效药物,其给药途径为鞘内注射,严重脊柱侧弯患者腰椎穿刺鞘内注射困难。文中总结了对1例复杂脊柱侧弯畸形的SMA2型患者进行Ommaya囊植入以及术后给药的过程,为该病的临床治疗提供一种新的给药方式。
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abstractsOmmaya reservoir implantation is generally used in the treatment of hydrocephalus and intraventricular drug administration. Ommaya reservoir implantation in the subarachnoid space of the spinal cord for the intrathecal drug administration has not been carried out in China, and only several reports can be retrieved from PubMed. About 60%-90% of untreated patients with spinal muscular atrophy type 2 (SMA2) who survive to adulthood often have complex scoliosis and joint deformities. Nusinersen is an effective drug for the treatment of SMA2. And the route of administration is intrathecal injection, which is difficult for patients with severe scoliosis. This article summarizes the process of Ommaya reservoir implantation and postoperative drug administration in a patient with complex scoliosis type SMA2, which provides a new method for clinical treatment of this disease.
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