换一批神经系统遗传疾病脑类器官模型构建的优势与挑战
Advantages and challenges of brain organoid modeling for genetic diseases of the nervous system
摘要脑类器官是由人类胚胎干细胞或人类诱导多能干细胞产生的自组织3D聚集体，其细胞类型和结构类似于胚胎人脑，是一个研究神经遗传疾病的良好体外模型，已在神经遗传疾病研究中较为广泛应用。文中将探讨脑类器官在神经系统遗传疾病模型构建中的优势与挑战。
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abstractsBrain organoids are self-organized 3D aggregates generated by human embryonic stem cells or human induced pluripotent stem cells. Their cell type and structure are similar to embryonic human brain, which are good in vitro models for the study of neurogenetic diseases and have been widely used in the study of neurogenetic diseases. This paper will discuss the advantages and challenges of brain organoids in the modeling of genetic diseases of the nervous system.
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关键词
脑类器官神经遗传疾病诱导多能干细胞疾病模型Brain organoidsNeurogenetic diseasesInduced pluripotent stem cellsDisease model
栏目名称
DOI
10.3760/cma.j.cn113694-20231226-00404
发布时间
2024-09-08（万方平台首次上网日期，不代表论文的发表时间）
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