摘要强制正常化（FN）是一种罕见的癫痫性精神疾病，通常表现为在改变抗癫痫发作药物（ASM）剂量或开始使用一种新药后，患者癫痫发作停止并出现急性精神病，同时伴有脑电图的矛盾性正常化。本文报道了1例青年女性Lennox-Gastaut综合征患者，在改变ASM方案后出现2次FN，经ASM减量和奥氮平治疗后好转。进一步文献回顾总结FN的临床特点发现，FN患者中女性略多于男性，发病多见于青壮年，多为难治性癫痫。精神行为障碍以妄想、幻觉、行为怪异、躁狂、抑郁、分离障碍为主要表现。改变ASM方案是主要的诱发因素。大部分患者通过调整ASM或加用抗精神病药物后好转。通过对该病例的分析，旨在增加对FN的临床特点、精神行为异常特点、治疗及预后等的认识并提高疾病的临床诊疗水平。

abstractsForced normalization (FN) is a rare epileptic psychiatric disorder that usually characterized by the disappearance of seizures and acute psychosis in patients with paradoxical normalization of the electroencephalogram following a change in the dose of antiseizure medication (ASM) or the initiation of a new medication. This article reports a case of a young female patient with Lennox-Gastaut syndrome who developed FN twice after a change in the ASM regimen, which improved after ASM reduction and olanzapine treatment. Further literature review summarizing the clinical features of FN found that there were slightly more females than males in patients with FN, the onset was more common in young adults, and most patients had refractory epilepsy. The psychiatric and behavioral abnormalities included delusions, hallucinations, bizarre behavior, mania, depression, and dissociation. The changes in ASM were the main inducing factor. Most patients improved by adjusting ASM or adding antipsychotic drugs. By reviewing this case, this article aims to increase awareness of the clinical features, characteristics of mental behavioral abnormalities, treatment and prognosis of FN and to improve the clinical management of the disease.