摘要Albumin is the most abundant protein in plasma and is synthesized primarily in the liver.It has a variety of biological roles,such as increasing colloid os-motic pressure,and performing antioxidant,anti-inflam-matory,and substance transportation functions.Several studies have confirmed that albumin has neuroprotective effects and it has been used in the treatment of cerebral edema and increased intracranial pressure.In this review we focus on the neuroprotective effects of albumin in ischemic stroke,such as the reduction of cerebral ede-ma,antioxidant effects,protection of neuronal cell mem-branes,and increased cerebral blood flow.In addition,we summarize preclinical and clinical studies of albumin in ischemic stroke.We believe that the neuroprotective role of albumin should be re-investigated in the era of reper-fusion therapy.