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The mechanisms that regulate neuronal pyroptosis in cerebral ischemia-reperfusion injury:current theories and recent advances

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学术成果认领

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摘要Early or ultra-early pharmacological thrombolysis together with mechanical thrombectomy are key treatments for ischemic stroke,and both are aimed at vascular recanalization and improved collateral circula-tion.While these methods enhance tissue perfusion in the ischemic penumbra,they also trigger complex neurotoxic reactions,including apoptosis,acidosis,ion imbalance,oxidative stress,and pyroptosis,exacerbating cerebral ischemia-reperfusion injury (CIRI).Pyroptosis,a recent-ly discovered form of programmed cell death driven by inflammation,plays a significant role in neuronal death during CIRI.This study reviews the regulatory mecha-nisms of pyroptosis in CIRI.

作者 Hui Li ^[1] Lu Liu ^[1] Chen Zhou ^[2] Xunming Ji ^[3] 学术成果认领

作者单位 Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China ^[1] Beijing Institute of Brain Disorders,Laboratory of Brain Disorders,Ministry of Science and Technology,Collaborative Innovation Center for Brain Disorders,Beijing Advanced Innovation Center for Big Data-Based Precision Medicine,Capital Medical University,Beijing 100069,China ^[2] Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Beijing Institute of Brain Disorders,Laboratory of Brain Disorders,Ministry of Science and Technology,Collaborative Innovation Center for Brain Disorders,Beijing Advanced Innovation Center for Big Data-Based Precision Medicine,Capital Medical University,Beijing 100069,China ^[3]

关键词 cerebral ischemia-reperfusion injury pyroptosis connexin 43

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Review

DOI 10.3868/j.issn.2096-0689.2024.01.002

发布时间 2024-12-16（万方平台首次上网日期，不代表论文的发表时间）

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