摘要Increasing evidence demonstrated that the blood-brain barrier (BBB) was involved in develop-ing cerebral amyloid angiopathy (CAA). The BBB par-ticipates in the neurovascular coupling and regulates the transport of substances,which is closely related to neuro-degenerative diseases. In CAA,the deposition of amyloid beta (Aβ) in arteries,capillaries,and arterioles of menin-ges and cerebral cortex results in the destruction of the BBB,chronic inflammatory response,chronic cerebral hypoperfusion,and dysfunction of the neurovascular unit,which eventually leads to neurodegeneration. At the same time,CAA is an age-related disease. Patients with CAA often have some risk factors for cerebrovascular diseas-es,such as hypertension and diabetes,which can further aggravate the damage to the BBB. Thus,it is of great sig-nificance to pay attention to the BBB in the pathogenesis and future intervention targets of CAA. Therefore,this manuscript reviewed the dysfunction of the BBB in CAA.